Abstract: Abstract Objective: To investigate the expression of Antibiotic Peptide LL-37and HD5 in the vaginal fluid of vulvovaginal candidiasis（VVC）and recurrent vulvovaginal candidiasis(RVVC). Methods：Human vaginal fluid from 31 VVC patients, 27 RVVC patients and 30 healthy women ( the control group)were collected respectively.Enzyme-linked immunosorbent assay ( ELISA)was applied to detect the levels of antibiotic Peptide LL-37and HD5 which were infectded by candida albicans that were found by culturing in the CHROMagar. Results: Both the LL-37and HD5 were found in the VVC group、RVVC group and the control group. The levels of LL-37and HD5 of VVC group were higher than the control group.The level of LL-37 of RVVC group was higher than the control group. The level of HD5 had no difference between the RVVC group and the control group. The levels of LL-37 and HD5 had no difference between the RVVC group and the VVC group. Conclusions: The level of LL-37 may play an important role in the pathogenesis of VVC and RVVC. The level of HD5 may play an important role in the pathogenesis of VVC , while may had no relationship with RVVC.

Key words: Vulvovaginal candidiasis, Antibiotic Peptide LL-37, HD5, Correlation