Abstract: Example of hospital admissions in children with cough 3 days to a local hospital because of abnormal physical examination of liver enlargement and the suspected presence of acute congestive heart failure, but given the appropriate treatment in the after-effects worse, they suspected the blood system disease Guer into our hospital. The patient is hospitalized, according to their symptoms and signs should be considered hepatosplenomegaly and pulmonary infection and, therefore Jicha liver function, suggesting that there is significantly abnormal liver enzymes, abdominal B-us show diffuse liver disease, liver and spleen increased bone marrow punctures were reported as hyperplasia of bone marrow of three lines, I no obvious abnormalities, combined with children HPVB19-PCR (+), it is considered man parvovirus B19 infection in infants caused by the outbreak of hepatitis as fast anti-virus, Liver, nutrition support, strengthen management and treatment of respiratory nursing. Children diagnosed, treatment is effective, rapid retraction of the liver and spleen, the liver function recovered well, better hospital. This drew the majority of clinicians should be aware, for infants and young children should pay special attention to liver enlargement of the spleen physical examination of the case, where the liver in children with splenomegaly should take into account both infected and uninfected infection factors, and timely liver blood tests function, in order to avoid misdiagnosis, delayed treatment.

Key words: Human parvovirus B19, infant fulminant hepatitis, Misdiagnosis