Abstract:

[Abstract] Objective To investigate the expression of CXCR7in gastric carcinoma tissues and the role of CXCR7 in tumor growth, adhesion and invasion of gastric cancer. Methods The expression levels of CXCR7, Survivin, CD44v6and matrix metalloproteinase (MMP)-3were detected by immunnohistochemistry method in gastric cancer specimens came from 160patients (gastric cancer group) and30specimens of normal gastric tissues (control group).Results The expression of CXCR7protein was significantly higher in gastric cancer group than that of control group (P<0.05). The positive CXCR7 staining was significantly different with tumor size, depth of invasion, lymph node metastasis and clinical staging (P<0.05). CXCR7expression was positively correlated with Survivin, CD44v6and MMP-3. Conclusion CXCR7might take part in progression of gastric cancer by anti-apoptosis (Survivin). CXCR7might take part in the lymph node metastasis of gastric cancer and mediate the adhesion and invasion by CD44v6and MMP-3.

Key words: gastric cancer, CXCR7, Chemokine receptor, immunnohistochemistry