Abstract:

[Abstract] Objective  To investigate the infiltration of dendritic cell (DC) in Vocal cord polyp, laryngeal leukopla? kia and glottic squamous cell carcinoma，and to observe laryngeal mucosal lesions of the state of the immune microenvironment, and to research significance of DC on the development of glottic squamous cell carcinoma. Methods  The infiltration of S-100+ and CD83+DC in 20 cases of Vocal cord polyp, 47 cases of laryngeal leukoplakia, 45 cases of glottic squamous cell carcinoma tumor and 20 cases of laryngeal normal mucosa were examined using immunohistochemistry. Results  The number of S-100+ and CD83+DC were significantly higher in glottic squamous cell carcinoma, laryngeal leukoplakia and vocal cord polyp than that in laryngeal normal mucosa (P < 0.05). The number of S-100+ and CD83+DC were higher in laryngeal leukoplakia than that in glottic squamous cell carcinoma (P < 0.05). The number of S-100+ and CD83+DC in mild dysplasia and moderate dysplasia were less than that in severe atypical hyperplasia (P < 0.01). In glottic squamous cell carcinoma, S- 100+ and CD83+ DC with poor-differentiated was significantly less than that with well-differentiated (P < 0.01). Conclusion  Changes in the number of dendritic cell was found in vocal cord polyp, laryngeal leukoplakia and glottic squamous cell carcinoma, which indicated that there were an abnormal immune status. Changing of dendritic cell in laryngeal mucosa plays an important role in laryngeal cancer development.

Key words: laryngeal leukoplakia, glottic squamous cell carcinoma, dendritic cells, S-100, CD83