Abstract: Abstract: Objective To evaluate the relationship in the cost of hospitalization，in hospital day and the effect of Intrathecal injection methylprednisolone for acute multiple sclerosis(MS). Methods 70cases were divided into two groups as intrathecal methylprednisolone group and methylprednisolone impact group，then evaluated the reduction of Kurtzke expanded disability status scale（EDSS）and the rate of side effects at different time after treatment. The average total cost of hospitalization， average cost of hospitalization per day， the proportional of drugs were analysed with the software of SPSS13.0. Results Aerage improvement in mean expanded disability status scale （EDSS）in intrathecal methylprednisolone group ，methylprednisolone impact group and dexamethasone group at 5day were（1.088±0.995）scores and（0.429±0.763）scores ，at 15day were（1.483±1.332）scores and（1.479±1.326）scores，the average costs of hospitalization were （6520.78±1536.26） yuan and （11059.01±2356.32） yuan ， and the average costs of hospitalization per day were （532.22±97.37） yuan and（664.01±105.68） yuan，average hospitalizing days were （12.8±2.3） days and（20.7±3.9） days . Conclusion The improvement of EDSS scale of intrathecal methylprednisolone group were significantily obvious compared with the control group during earlier period of treatment. Intrathecal methylprednisolone therapy worked faster compared with the control group, the average total cost of hospitalization is the and average hospitalizing days is more shorter，the proportional of drugs of intrathecal methylprednisolone group is decrease. The average total cost of hospitalization and average cost of hospitalization per day in methylprednisolone impact group costs are the most ，the proportional of drugs is increase. the average hospitalizing days of methylprednisolone impact group is the longer.

Key words: Multiple sclerosis(MS), Methylprednisolone（MPS）, Intrathecal injection, Cost of hospitalization