Abstract: 　　　Abstract: objective to investigate the relationship between contrast-enhanced sonographic characteristics and tumor microvessel density (MVD) in pleural-based lung cancer. Methods 40 patients with biopsy-proven pleural-based lung cancer (22 patients with adenocarcinoma and 18 patients with squamous cell carcinoma) performed contrast-enhanced sonography prior to biopsy procedure. MVD of the biopsy specimens were assessed by histochemical staining using a mouse antihuman CD34 monoclonal antibody. Peak enhancement and enhancement index derived from time intensity curve were correlated with MVD. Results Lung adenocarcimoma showed statistically higher value than squamous cell carcinoma in respect to PE , EID, and MVD（P＜0.01）. A linear positive correlation was reveal between enhancement parameters (PE, EID) and MVD for both adenocarcimoma and squamous cell carcinoma（P＜0.01）. Conclusion Peak enhancement and enhancement index of pleural-based lung cancer on contrast-enhanced sonography were correlated with tumor’s MVD. This indicates that contrast-enhanced sonography can be used to evaluate angiogenesis of pleural-based lung cancer.