Abstract: Abstract Objective：To study the expression and clinical significance of Bcl-2 and Ki-67 in prostatic carcinoma．Methods：Immunohistochemical ABC was used to determine the expression of Bcl-2 and Ki-67 in 20 cases of BPH tissue and 60 cases prostatic carcinoma．Results: The positive incidences of Bcl-2 and Ki-67 expression in BPH tissue were5% 、15%,and prostatic carcinoma were 63%±48.2%、70%±46.9%.The expressionof Bcl-2 and Ki-67 correlated to preoperative serum prostate-specific antigen level，extraprostatic extension，the degree of histobogical grade and clinical stage(P<0.05).The expression of Bcl-2 had a positive relation with expression of Ki-67（r=0.167 P<0.05）. Conclusion；The combined detection of Bcl-2 and Ki-67 proteins can be used to evaluate the incidence of prostate carcinoma development, prognosis, and provide an important basis for drug treatment .