Abstract: Objective To evaluate the clinical diagnosis and surgery treatment of hepatic angiomyoilpoma(HAML).Methods 5 HAML cases were reviewed retrospectively.The average age of the 5 patients(1 male and 4 female) was 50.8 years old.Serum tumor markers levels were all within normal limits. Imaging studies include abdominal US, CT scan in all patients, contrast enchanced US(CEUS) in 3 patients,and MRI in 2 patients. All these 5 patients underwent liver resection,The diagnoses were confirmed by pathologic examination and immunochemical assays with a broad panel of antibodies.Results The postoperative pathology showed HAML in all the patients; and the positive rate of HMB-45 staining by immunohistochemistry was 100%(5/5).Accurate preoperative diagnosis of HAML were made in 1 patients by CEUS,2 patients by CT,and 1 patients by MRI. Folow up of 6 months to 36 months in all 5 patients with no evidence of recurrence.Conclusions There are no specific signs and symptoms in HAML patients;The preoperative imaging diagnosis is difficult. surgical resection should be considered as a treatment choice for HAML.