Abstract: 【Abstract】Objective：To observe the clinical effect of Zilongjin piece combined with chemotherapy in treatment of advanced colorectal carcinoma．Methods： Total of 45 patients were randomly divided into chemotherapy combined Zilongjin piece therapy group(treatment group，TG)and simple chemotherapy group(control group，CG)．Results： TG and CG were compared in zhe efficacy ，there was no significant difference between the 2 group(P>0．05)；KPS score of TG and CG were statistically significant difference (p