Abstract: Abstract Objective:To compare the effects of pioglitazone or insulin therapy on blood glucose and serum uric acid in type 2 diabetes.Method: one hundred and thirty-three patients with type 2 diabetes mellitus complicated with hyperuricemia randomly divided into 3 groups.Fasting glucose, 2-hour glucose, glycation hemoglobin(HbA1c), serum uric acid, microalbuminuria(MAU), serum creatinine(Cr), total cholesterol(TC) and triglyceride(TG) were measured before and after 12 weeks of treatment with pioglitazone, insulin or conventional treatment. Results:Fasting glucose, 2-hour glucose, HbA1c, serum uric acid, TC and TG decreased significantly at 12 weeks in patients receiving pioglitazone(P<0.05). Fasting glucose, 2-hour glucose and HbA1c decreased significantly at 12 weeks in patients receiving insulin(P<0.05).At 12 weeks, the insulin group had lower fasting glucose, 2-hour glucose and HbA1c, than the pioglitazone group and the insulin group(P<0.05). The pioglitazone group had lower serum uric acid than the insulin group .(P<0.05). The conventional treatment.group had lower serum uric acid than the other group(P<0.05). Conclusions:Insulin lead to a decrease on blood glucose decrease; pioglitazone lead to adecrease on serum uric acid.For type 2 diabetes who also have hyperuricemia, without gout,pioglitazone is a better choice.

Key words: pioglitazone, insulin therapy, type 2diabetes, hyperuricemia