Abstract: Objective：To investigate the relationship between platelet Factors and recurrent native AVF dysfunction in MHD(maintenance hemodialysis) patients．Methods：The studied subjects were divided into three groups(group A included 18 MHD patients with recurrent native AVF dysfunction, group B included 30 MHD patients with longer native AVF survival and group C included 12 healthy volunteers as controls). The expression of platelet activation markers(CD62P，CD63) were measured by flow cytometry（FCM）, and all studied subjects were detected platelet aggregation indued by arachidonic acid(AA) and adenosine diphosphate(ADP). All those results were compared among groups．Results：The level of activated platelet and platelet aggregation in group A is much higher than in group B and group C(P <0.05 or P <0.01). The logistic analysis showed that CD62P and PAgTADP were the risk factors of recurrent native AVF failure. Conclusion： The higher level of platelets activating and platelet aggregation is associated with recurrent native AVF dysfunction in MHD patients

Key words: native arteriovenous fistula, platelet activation, platelet aggregation, hemodialysis