Abstract: Abstract Objective: To analyze the difference of clinical features, etiology, medication, misdiagnosed, and negative emotions in the different sexual non-coronary patients with chest pain . Methods: The CAG / CTCA and SPECT examination confirm the diagnosis in patients with non-coronary chest pain,and these patients were divided into male and femal groups by sex . The two groups were Summarized and analyzed in the clinical features, misdiagnosis, etiology, drug use and mental status. Results: 141 cases patients of non-coronary heart disease patients included 85cases females and 56 cases males. The female patients were misdiagnosed for a longer time. The onsetal age of female patients were earlier than males ,and more likely associated with radiation of pain and ECG ST-T changes. The commonal cause of female patients were dued to functional diseases of social and psychological factors . (p <0.05). The mindiagnosis of female patients didn’t timely perform CAG / CTCA examination by themselves. And the male patients didn’t delay diagnosis by obeying the doctor suggestion. It was excluding coronary heart disease before that the using medication proportion of female patients was significantly higher than male patients. after excluding coronary heart disease, 91.1%women and 100% of men stopped taking drugs.The patients had particularly negative emotions by the SDS, SAS score before exclusion of coronary heart disease,and after excluding coronary heart disease,the negative emotions decreased (p <0.01),which had no significant difference between different genders. Conclusion: The clinical characteristics of non-coronary heart disease patients with chest pain is significant gender differences. The female patients are more likely long-term misdiagnosis.Once we highly suspected patients with coronary heart disease,we should make them do CAG / CTCA examination as early as possible, in order to prevent drug abuse and reduce the negative emotional and economic losses.

Key words: coronary heart disease, gender differences, clinical features, negative emotion