Abstract: Objective To explore the relationship between CAG polymorph- isms of androgen receptor gene and acute myocardial infarction in men. Methods 112 acute myocardial infarction patients and 118 healthy men were selected. The length of CAG repeats in the peripheral blood AR gene was examined by PCR and direct sequencing. Results For the AMI patients and the controls, the numbers of CAG repeats ranged from 12-33,with mean values 23.09±3.520 and 20.33±3.654,respectively.There were statistically significant differences between two groups. Men with CAG repeats length of 23 or longer may be in high risk of AMI(odds ratio,4.479 ；95% CI 2.564-7.824，P<0.001),compared with men with CAG repeats length shorter than 23.Conclusions The CAG repeat polymorphism in the androgen receptor is associated with acute myocardial infarction, Men with CAG repeats length of 23 or longer may be in high risk of acute myocardial infarction .

Key words: 男(雄)性