Abstract: Objective: To investigate Expression and significance of EMP1 in oral squamous cell cancer tissues. Methods: Immunohistochemical method was used to determined expression of EMP1 in 60 of oral squamous cell cancer (OSCC) tissues. Statistical analysis was performed for the correlation between expressive intensity of EMP1 and availably clinic parameters, the difference between early and advanced tumors and between lymph node and no lymph node metastasis.Sensitivity and specifity of expressive scores of EMP1 used for diagnosis were identified. Results: Expressive intensity of EMP1 correlated with clinic stage (P=0.002) and lymph node metastasis or not (P=0.044). There was a significant difference existed between early and advanced stage, lymph node and no lymph node metastasis (P=0.003, and P=0.045, respectively). Sensitivity and specifity of expressive scores of EMP1 used for diagnosis of lymph node metastasis and early and advanced OSCC were 61.90%, 77.80% and 70%, respectively. Conclusion: Expression of EMP1 was correlated with lymph node metastasis or not and clinic stage, which may has reference significance for clinical practice.

Key words: oral squamous cell cancer immunohistochemistry expression significance