Abstract: Objective: To understand the clinical effective of lamotrigine for Children patients with newly diagnosed epilepsy. Methods: 80 cases of children patients with newly diagnosed epilepsy, were treated with lamotrigine. LTG was used originally at a dose of 0.5mg/(kg?d), 4 weeks achieved the goal dosage (4.0-5.0mg/(kg?d)). We observed their changes of seizure frequencies compared with the basic-line before the treatments. Result: There are 31 patients seizure free, 27 patients whose frequencies were reduced by more than 75%, 8 patients’ frequencies were reduced by more than 50%. The total effective reached 82.5％. Patients with GTCS obtained the best effects. The total effective reached 95.0％. Related adverse effcts included asthenia, somnolence, skin rashes. These adverse effects disappeared spontaneously without any special treatment. Conclusion: lamotrigine is a safe effective drug for Children patients with newly diagnosed epilepsy.

Key words: Antiepilepsy drug, lamotrigine(LTG), Monotherapy