Abstract: Abstract Objective：To explore the therapeutic effects of replacement therapy with domestic recombinant human growth hormone(rhGH) on the liner growth and the fasting blood-glucose in children with growth hormone deficiency(GHD) . Methods: 25 GHD children were treated with rhGH and the dose is 0.1-0.15U/（kg.d）.They use it 6-7times every week by subcutaneous injection .Height (Ht) and weight (Wt) were measured by designate personnel using the same measuring tool before and after treatment for 3 and 6months .Body mass index (BMI) and Height standard deviation score (HtSDS) were computed. Fasting blood-glucose test were performed to test fasting blood-glucose (FBG) during 8 am. And children had no food or drink at least 8 hours before the test. Results：After 3 and 6 months of rhGH therapy, the HtSDS increased from -2.30±0.44 to-1.77±1.23(P<0.05), -1.74±0.58 (P<0.001) and the HV increased observably (P<0.001). FBG increased after the 3 and 6 months treatment (P<0.05), but still in a normal range and the FBG was age-related (r=0.418、0.456，P<0.05). Conclusion：The replacement of the rhGH can improve the height of children with GHD and affect the fasting glucose in children with GHD. We should dynamically monitor the fasting glucose during the treatment especially for the children with bigger initial treatment age.