Abstract: Objective To explore the clinical significance of BNP for risk stratification,treatment and prognosis in submassiv PTE.Methods A total of 84 patients with confirmed submassiv PTE were divided into two groups according to serum BNP levels,including Group A(n=50),BNP>90pg/ml and Group B(n=34),BNP≤90pg/ml.Meanwhile,the patients in Group A and Group B were respectively divided into two groups according the treatment:thrombolysis combined with anticoagulant therapy or simple anticoagulant therapy.The clinical feature,ECG,ABG,echocardiography and prognosis were analyzed and compared. Results There were significant differences in dyspnea,chest pain,heart rate,respiratory frenquency,cyanosis,pericardial or pleural effusion,accentuated S2,abnormal myocardial enzyme，arterial blood PaO2,A-aDO2，oxygenation index,severity of ECG,RAE or RVE,PASP,mid to deep degree of tricuspid regurgitation between Group A and B (P<0.05).There were significant differences in clinical key events:PTE recurrence,pulmonary artery hypertension,pneumocardial disease between Group A and B(P<0.05).There were significant differences in △PASP,therapeutic effect,pulmonary artery hypertension,pneumocardial disease between two sub-groups according to the treatment:thrombolysis combined with anticoagulant therapy or simple anticoagulant therapy of Group A.There were no significant differences between two sub-groups of Group B. Conclusion Serum BNP level is significant for submassive PTE patients to stratify the risk,select the fittest treatment and test the prognosis.

Key words: BNP, submassive PTE, risk stratification, treatment, prognosis