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Abstract: To measure the serum visfatin level in gestational diabetic patients and study the correlation between visfatin level and insulin resistant degree. Methods: According to the ADA standard, 106 pregnant women were divided into three groups. Gestational diabetes mellitus group (GDM, n=50), the group with gestational impaired glucose tolerance (GIGT, n=24), the control group with normal glucose tolerance (NGT, n=32). Recorded the clinical and perinatal data. Serum visfatin levels were measured by ELISA method and insulin levels were measured bychemiluminescence. Analyze the difference among these groups and study the relationship between visfatin and body mass index, , insulin-resistant degree. Results: The serum visfatin level in GDM group(84.04±22.15 ng/ml)was higher than GIGT group(65.71±13.38 ng/ml) and NGT group (56.11±10.39 ng/ml)(F=26.562, P=0.001)。There were also difference in serum insulin level among three groups, the value in GDM, GIGT and NGT group was 27.91±10.31mIu/L, 26.94±6.69mIu/L and 22.32±3.37mIu/L(F=4.984,P=0.009). Serum visfatin level was positively related with insulin level and HOMA-IR (r=0.636, 0.738, all P= 0.001).There were also relationship between visfatin level and TC, TG, HbA1C value. Conclusion: High-expressed visfatin increases the insulin-resistance in pregnant women. Visfatin participates the metabolic disturbance in glucose and lipid, this maybe a mechanism of GDM occurrence.
Key words: gestational diabetes mellitus, visfatin, insulin-resistance
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https://www.tjyybjb.ac.cn/EN/Y2011/V39/I7/577