Abstract: Abstract: Objective To observe the Effect of the Huangqi Injection on the Mitochondrial Membrane Potential (MMP) and GSH in ADR mice. Methods 60 Kunming mice (weighing 18～22g) are randomly divided into five groups:they are the normal control group ,the adriamycin (ADR) group,the Huangqi injection (large、middle、small) group ,instruct the molder of the doxorubicin induced cardiotoxicity in mice.Test the coefficient of the heart,the contentof the GSH. Flow Cytometry are used to analysis in Mitochondrial Membrane Potential in this study. Results 1. heart coefficient: Compared with the adriamycin(ADR) group, Huangqi injection groups can relieve the heart of tumefy(P<0.01); 2.the content of GSH: Compared with the adriamycin(ADR) group, Huangqi injection groups can increase the GSH(p<0.01) .3. the MMP: Huangqi injection groups can stable the cardio-muscle cell mitochondrial membrane potential, Compared with the adriamycin(ADR) group，there are obvious statistical differences (P<0.01). Conclusion:Huangqi injection can relieve the heart of tumefy,increase the GSH, stable the cardio-muscle cell mitochondrial membrane potential，restrain the apoptosis cardiac muscle cell to protect cardiac muscle cell.

Key words: Huangqi Injection, Adriamycin, MMP, GSH