Abstract: Objective: To investigate HBYYRJ prophylactic effect on mouse liver fibrosis by reduced by ConA. Methods: Eighty rats were randomly divided into 7 groups, normal group(n=8), model group(n=16), HBYYBJ low dosage treatment group(n=14), middle dosage treatment group(n=14), high dosage treatment group(n=14), composed formula treatment group(n=14), and colchicine treatment group(n=14). Rat models of hepatic fibrosis were established by injection of ConcanavalinA .HBYYBJ was used for prevention of hepatic fibrosis. Histologic observation of the liver tissue was done with H & E stain and collagen stain.。Result: The degree of the liver fibrosis staging are significantly higher than normal contrast group (P<0.01). The three groups of HBYYRJ, the degree of hepatic fibrosis are significantly lower than model group (P<0.05).The degree of liver fibrosis The content of HBYYRJ in model group was significantly higher than normal contrast group (P<0.01) HBYYRJ medium and low groups was significantly lower than model contrast (P<0.05). HBYYRJ can decreace the degree of HA and PCⅢ. Conclusion: HBYYRJ has the preventive effect on the liver fibrosis with mice. Key words: ConA, liver fibrosis, hydroxyproline (Hyp), hyaluronic acid (HA), pre--collagenⅢ(PCIII)

Key words: ConA, liver fibrosis, hydroxyproline (Hyp), hyaluronic acid (HA), pre--collagenⅢ(PCIII), Balb/c