Abstract: Objective Evaluation on regular treatment (such as diuretics, angiotensin converting enzyme inhibitor and Digitalis) inefficacy of severe Decompensated congestive heart failure in elderly patients, intravenous injection of Levosimendan (Levosimendan Injection) the effectiveness and safety. Methods General correction of 40 cases of severe congestive heart failure in the elderly patients with heart failure therapy no better randomly divided into Group (20 cases, granting of Levosimendan therapy) and a control group (20 cases, give the metres of milrinone therapy). Observation on the treatment of the two groups, BNP and hemodynamic changes before and after clinical symptoms. Results Comparison of the two groups, after treatment, Levosimendan group BNP loss, difficulty in breathing in patients with improved insight group is more notable than milrinone (p< 0.01), and blood pressure decrease is more pronounced in milrinone Group (p﹤0.01). Between difference in improving the symptoms of heart failure has a significant (p ﹤0.01).. Conclusion: Levosimendan in treatment efficacy and safety are superior to intravenous milrinone in patients with severe heart failure.

Key words: Levosimendan, milrinone, HF