Abstract: Abstract Objective:To observe the efficacy and adverse reaction of coelom hyperthermic perfusion chemotherapy in the treatment of malignant pleural effusion and ascites. Methods: 58 cases in the treatment group were from oncology inpatient of our hospital from February 2010 to August 2010, while 58 cases in the control group were from June 2009 to February 2010. All patients were placed Central Venous Catheter by ultrasound –guided, and the effusion was drained properly. Treatment group : two-thirds of the chemotherapeutic drugs with Lidocaine Hydrochloride 0.1g and Dexamethasone 5mg were put into 2000~3000ml normal saline，and then the medicinal liquid was perfused into body cavity by indwelling drainage tube circularly，maintainning at 43℃~45℃with coelom hyperthermic perfusion therapy machine and keeping 60 minutes,finally the remaining one-third of the chemotherapeutic drugs with normal saline 100ml was perfused into body cavity. Control group : the chemotherapeutic drugs were put into 50ml (thoracic cavity) or 1000-2000ml (abdominal) normal saline heated to 45℃ in advance，and then the medicinal liquid was perfused into body cavity by indwelling drainage tube quickly. The therapeutic schedule was applied once every three weeks in each group. The efficacy and adverse reaction were evaluated after two cycles. Results : The total effective rate in the treatment group was 89.66%, while that in the control group was 67.24%（P<0.01）. The adverse reactions were similar with no significant differences in the two groups.Conclusion：Coelom hyperthermic perfusion chemotherapy can effectively control the growth of malignant pleural effusion and ascites with mild adverse reaction. It’s worthy of applying to the clinical.

Key words: coelom, hyperthermic perfusion chemotherapy, malignant pleural effusion and ascites, coelomhyperthermic perfusion therapy machine, adverse reaction