Abstract: Objective: To investigate the clinical efficacy of Uremia Clearance Granules-enema on uraemic itching. Methods: 83 patients were randomly divided into control group with 21 cases, activated carbon –enema group with 30 cases and Uremia Clearance Granules-enema group with 32 cases.All groups were treated with hemodialysis（3 times per week）. Activated carbon-enema group and Uremia Clearance Granules-enema were either treated with additional enema. The uraemic itching was analyzed pre- or post-treatment,and BUN、Cr、UA、Hb、hs-CRP、Ca、P and PTH were detected respectively in the three groups. Results: Both enema groups have significantly effect on uraemic itching compared with the control group（P <0.05）. However, uraemic itching was alleviated much better in the Uremia Clearance Granules-enema group (P < 0. 05). The BUN 、Cr、UA、hs-CRP、Ca、P and PTH were significantly improved in both enema groups(P < 0. 05). However, in comparing with Activated carbon-enema group, hs-CRP、PTH and Hb were improved more better(P < 0. 05). Conclusion: Uremia Clearance Granules-enema can effectively relieve uraemic itching and reduce the microinflammation state in hemodialysis patients.

Key words: Uremia Clearance Granules, hemodialysis, enema, uraemic itching, microinflammation state