Abstract: Abstract Objective： To investigate the effects and safety of low molecular weight heparin combined with dextran-40 on pregnant women with oligohydramnios. Methods： A total of 73 pregnant women who were diagnosed as oligohydramnios were randomized into combined therapy group(n=21), low molecular weight heparin (LMWP) group(n=21) and control group(n=32). The combined therapy group was treated with 0.4 mL of LMWP and 500 mL of 5% dextran-40. LMPW group was treated with 0.4 mL of LMPW only. The control group was given 500 mL of 5% glucose infused with 40 mg of Adenosine triphosphate，0.4 g of carnine，100 u of coenzyme A and 250 mL of compound amino acids. Amniotic fluid index(AFI) and coagulogram markers were measured after a course. Results：The improvement rate were significant higher in combined therapy group(90.5%) and LMWP group(80.0%) than in control group(46.9%)（P＜0.05）, but there was no difference between these 2 groups（P＞0.05）. The average increasing volume of AFI was significant different between the 2 groups（P＜0.05）. The combined therapy group(4.41±0.63) was better than LMWP group(3.95±0.57). There was no difference in blood coagulation indication between before and after treatment in each group（P＞0.05）. Conclusion： LMWP combined with dextran-40 could improve volume of amniotic fluid effectively in patients suffered with oligohydramnios, and it was safe to both mothers and fetuses.

Key words: oligohydramnios, dextrans, heparin, low-molecular-weight, therapies, investigational