Abstract: Objective To investigate the correlative factors of ambulatory arterial stiffness index (AASI) and the relationship with target organ damage (TOD) in primary hypertensive patie- nts. Methods A total of 330 hypertensive inpatients were included in the study and divided into two groups according to the AASI:low AASI group (n=167) and high AASI group(n=163).AASI was calculated obtained from 24-hour ambulatory blood pressure monitor (ABPM). The clinical data were collected including general information ,the data of ABPM, coronary lesions,left ventricular mass index (LVMI), estimated glomerular filtration rate(eGFR) and ankle brachial index(ABI) to compare between the groups.Results The levels of age(64.91±9.70vs59.12± 10.00) ,the proportion of diabetes(33.8%vs14.8%), the proportion of non-dipper(65.6% vs43.7%), 24 hours pulse pressure (PP)(65.27±11.31 vs56.06±10.51),24 hours diastolic blood pressure standard deviation（DBPSD)( 9.64±2.47 vs8.31±2.31), LVMI(125.74±29.65 vs107.69±23.23), coronary lesions(1.78±1.10 vs1.27±1.07) and the proportion of periphreral vascular disease(27.3% vs16.4%) were higher in the high AASI group than those in the low group ( P<0.01) ,the levels of eGFR(85.31±20.31 vs99.67±17.76) were inverse.In the correlation analysis,AASI was positively associated with coronary lesions (r=0.235), LVMI(r=0.168), periphreral vascular disease(r= 0.167),negatively with eGFR(r=-0.187).In multiple linear regression analysis model,independent predictors of AASI were age,diabetes, PP, DBPSD,non-dipper.Conclusion AASI correlated with age, diabetes,PP and blood pressure variability, non-dipper. The higher level of AASI may relate to the development of TOD in primary hypertensive inpatients.

Key words: hypertention, ambulatory arterial stiffness index, target organ damage