Abstract: 【Abstract】Objective To investigate the correlation of XRCC1 Arg194Trp Arg399Gln SNPs with radiotherapy response of squamous cell carcinoma of cervix. Methods Polymorphisms Arg194Trp、Arg399Gln of XRCC1 gene in 73 cervical cancer patients were analyzed by mismatch amplification polymerase chain reaction (MAMA-PCR). Result Response to radiotherapy was not statistically significant in three genotypes, Arg/Arg, Arg/Trp, TrP/Trp of XRCC1 at codon 194(P>0.05).Neither was XRCC1 at codon 399.Conclusion SNP of XRCC1 gene at codon 194 and codon 399 could not predict clinical response of patients with squamous cell carcinoma of cervix to radiotherapy.

Key words: Cervical cancer, X-ray repair cross-complementing gene 1, Single nucleotide polymorphism, Radiothetapy sensitivity