Abstract: Objective To investigate the radiosensitizing effects of NiKeAn on H22 hepatoma- bearing mice． Methods To establish the mouse hepatoma H22 models which were divided into blank control group, pure radiation group, positive control groups, NiKeAn（high, medium and low）groups． After irradiated, observe the growth of tumor’s conditions, record epigenetic tumor irradiation time, calculated the delay time of tumor growth and enhancement factor（EF）． After 28 days, killed the mouse, stripped tumors and calculated inhibition rate． Results Compared with pure radiation group, NiKeAn （high, medium and low） groups had more significant radiosensitizing effects, and inhibited the tumor growth better．The enhancement factor of NiKeAn high group（2.13）was higher than Sodium Glycididazole group’s and Nicotinamide group’s． Conclusion NiKeAn can inhibite the tumor growth, and has the radiosensitizing effects on H22 hepatoma- bearing mice． It’s clinical practice prospect is broad．

Key words: NiKeAn, H22 hepatoma- bearing mice, Radiosensitization, Inhibition rate．