Abstract: [Abstract] 　Objective　To investigate the correlation between serum level of lectin-like oxidized low-density lipoprotein receptor-1(LOX-1) and acute coronary syndrome (ACS ). Method There are 121 patients with coronary heart diseases (CHD) confirmed by CAG including 75 ACS patients,46 SAP patients,and 50 healthy subjects as the control group. Every sample’s serum LOX-1 level is detected by ELISA method. Results　On admission, the concentration of LOX-1 in ACS, SAP and control group is (216.38±40.67) 、(181.51±34.66)、(154.43±27.41)μg/L respectively；There is remarkable statistical difference between ACS and SAP group,and so is it between SAP and control group.There is no statistical difference of the level of LOX-1 between immediately after PCI and that before PCI. 1 week after PCI，the level of LOX-1 is lower than that before PCI， but there is no statistical difference between them. Conclusions The serum concentration of LOX-1 is higher obviously in ACS patients,and it is related to the stability of coronary plaque ,which shows LOX-1 may serve as a potential marker of plaque instability and could be the important monitering markers for the severity of ACS.

Key words: acute coronary syndrome(ACS), lectin - like oxidized lowdensity lipoprotein receptor-1(LOX-1), percutaneous coronary intervention(PCI)