Abstract: Objective:To investigate effect of probucol on serum lipid, mast cells and atherosclerosis of New Zealand rabbits with normal diet or high fat /high cholesterol diet. Methods:Forty male New Zealand rabbits were respectively supplied with normal fodder, normal fodder and probucol, high fat /high cholesterol fodder, high fat /high cholesterol fodder and probucol, then observed for 4 weeks. The serum lipids were measured. Mast cells were detected by toluidine blue. Aorta atherosclerotic lesion area was measured with Sudan IV. Results:There was a significant decrease in serum triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol(P<0.05), the percentage of degranulated mast cells in aorta and in jejunum (P<0.001), aorta atherosclerotic lesion area (P<0.001) in high fat /high cholesterol fodder and probucol group than in high fat /high cholesterol fodder group. Conclusion:Probucol can decrease serum triglyceride, total cholesterol, low density lipoprotein cholesterol and high density lipoprotein cholesterol, the percentage of degranulated mast cells in aorta and in jejunum, aorta atherosclerotic lesion area of New Zealand rabbits with high fat /high cholesterol diet.

Key words: probucoldiet, atherogenicatherosclerosislipidsmast cellsaortarabbits, 兔