Abstract: Objective:To investigate protective effect of Ozagrel sodium on limb ischemia-reperfusion injury of lung in rats.Methods:60 SD rats were randomly divided into 3 groups:the normal control group,the limb-ischemia-reperfusion group,the Ozagrel sodium group. The model rats which underwent 4 hours ischemia and 2 hours reperfusion of hind limbs were made.The histological and ultra-structure changes were observed under light microscope and electron microscope, respectively. TXB2 and PGI2 levels in serum were separately measured by radio-immunoassay. We observed changes of MDA SOD XOD in lung tissue of different groups by colorimetry and observed changes of IL-8 and TNF-α in lung tissue of different groups by avidinbiotincomplex-ELISA. Results: Compared with the limb-ischemia-reperfusion group, The damage in lung tissues of the Ozagrel sodium group alleviate under optical microscopy and electron microscope.The levels of TXB2 and 6-keto-PGFla in serum decreased very significantly. The level of SOD was increased during reperfusion and the values of XOD and MDA were all decreased significantly. The levels of IL-8 and TNF-α in lung tissue were much lower. Conclusions: Ozagrel sodium can alleviate limb ischemia-reperfusion injury of lung in rats.

Key words: lung, ischemia reperfusion, IL-8, TNF-α, Ozagrel, rats