Abstract:

[Abstract] Objective To compare effects of compound Xueshuantong capsule and benazepril on inflammatory cyto? kines in type2diabetic patients with early diabetic nephropathy (DN), and its therapeutic mechanism thereof.Methods Ninety-four patients with type2diabetes were divided into diabetes without albuminuria group (DM，n=24) and early DN group (DN，n=70). DN group was then divided into three subgroups：group A (n=24) treated by benazepril alone, group B (n= 22) treated by compound Xueshuantong capsule and group C (n=24) treated by compound Xueshuantong capsule combined with benazepril for3months. Levels of fasting blood glucose, glycosylated hemoglobin, serum creatinine, blood urea nitro? gen, lipid profiles, fibrinogen and urinary albumin excretion rate (UAER) were examined before and after treatment. The se? rum levels of hypersensitive c-reactive protein (hs-CRP), interleukin- 6(IL-6) and tumor necrosis factor-α(TNF-α) were determined as well.Results The serum levels of hs-CRP, IL-6and TNF-αwere significantly higher in DN group than those of DM group (P<0.01). After treatment, the serum levels of UAER, hs-CRP, IL-6and TNF-αwere significantly re? duced in groups A, B and C compared with those before treatment (P<0.01), and which were decreased more significantly in group C. The levels of blood lipids and fibrinogen decreased obviously in group C compared with those of group A and B (P< 0.01). Conclusion Compound Xueshuantong capsule combined with benazepril not only can improve the blood fat and high coagulation state in patients, but also impossibly retard the development of early DN through decreasing serum concen? trations of hs-CRP, IL-6and TNF-αand inhibiting inflammatory reaction.

Key words: compound Xueshuantong capsule, benazepril, Diabetic nephropathy, high sensitivity C-reaction protein, interleukin- 6, tumor necrosis factor-α