Haemodynamic analysis in canine aneurysm model

doi:10.11958/j.issn.0253-9896.2015.10.013

Abstract

Abstract:

Abstract：Objective To explore a way to establish a stable, ideal and handy intracranial aneurysm model for related
studies. Methods Modified microsurgery technology was applied to establish sidewall, bifurcation, terminal and merged
types of aneurysm (n=7 in each type). Two weeks after operation, color Doppler ultrasound, magnetic resonance imaging
(MRI), magnetic resonance angiography (MRA) and intra-arterial digital subtraction angiography (IADSA) were performed
and computational fluid dynamics (CFD) was used for simulation analysis of aneurysm models. Biomechanical properties of
aneurysm wall tissues was analyzed by cell culture, then the above examinations were performed again after the aneurysm
was embolized by micro coil (MC). Results All models were successfully established, and the MC embolization of aneurysm
cavity achieved good efficacy. Vascular endothelial cells (VECs) proliferate well in vitro, and the VECs adhered to the sur⁃
face of biodegradable polymeric materials successfully and grow into VEC layer structure. Hemodynamics analysis was per⁃
formed in aneurysms model before and after embolization and relevant hemodynamic parameters was obtained. , Blood flow
velocity are 2-7 cm/s in aneurysm and 8-26 cm/s in its parental artery. Conclusion A stable, ideal and handy intracranial
aneurysm model was established and are essential in aneurysm related research.

Key words: hemodynamics, intracranial aneurysm, animal models

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