天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (9): 1102-1104.doi: 10.11958/20150390

• 临床研究 • 上一篇    下一篇

天津地区 SARS 患者康复十年后实验室检查指标分析

马龙艳， 孙昕△， 吴琦， 李莉， 武俊平， 于洪志   

  1. 天津市海河医院， 天津市呼吸疾病研究所（邮编 300350）
  • 收稿日期:2015-12-11 修回日期:2016-04-05 出版日期:2016-09-15 发布日期:2016-09-28
  • 通讯作者: 孙昕 E-mail:13302031999@126.com
  • 作者简介:马龙艳（1981）， 女， 主治医师， 硕士， 主要从事呼吸及危重症研究
  • 基金资助:
    天津市卫生局科技基金（2014KY17）

Laboratory analysis in patients with severe acute respiratory syndrome after ten years of convalescence in Tianjin

MA Longyan, SUN Xin△,WU Qi, LI Li, WU Junping, YU Hongzhi   

  1. Tianjin Haihe Hospital, Tianjin Institute of Respiratory Diseases, Tianjin 300350, China
  • Received:2015-12-11 Revised:2016-04-05 Published:2016-09-15 Online:2016-09-28
  • Contact: SUN Xin E-mail:13302031999@126.com

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摘要： 目的 了解感染严重急性呼吸综合征（SARS）患者康复 10 年后的血液实验室检查指标变化情况， 评估 SARS 对血液系统的影响。 方法 选取本院确诊的 25 例 SARS 感染患者（SARS 组）和 25 例健康人（对照组）， 检验并比较 2 组的血常规、肝肾功能、血脂、血糖、甲状腺功能、肿瘤标志物及 T 细胞亚群等指标。 结果 SARS 组的血钙高于对照组（mmol/L： 2.32±0.08 vs. 2.29±0.08， t=2.072， P＜ 0.05）， 甲状腺素也高于对照组（nmol/L： 119.95±29.09 vs. 96.39±14.26， t=3.681， P＜ 0.05）， 但结果均在正常范围， 无临床意义； SARS 组神经元特异性烯醇化酶（NSE）高于对照组（μg/L： 10.368±3.684 vs. 3.282±1.828， t=9.012， P＜ 0.05）， 仅 2 例稍高于正常范围， 但均未超过正常值上限 1 倍以上， 影像学仅见部分陈旧改变， 无临床意义； 余所有指标组间差异无统计学意义。 结论 SARS 病毒未对 SARS 感染患者血液系统、肝肾功能、甲状腺功能及免疫力造成长期影响， 未增加 SARS 感染患者罹患肿瘤的概率。

关键词: 严重急性呼吸综合征, 实验室检查指标, 甲状腺素, 神经元特异性烯醇化酶

Abstract: Objective To investigate the changes of blood test indexes in patients with severe acute respiratory syndrome (SARS) after 10 years of rehabilitation, and to evaluate the effects of SARS on blood system. Methods Twentyfive cases of SARS confirmed in our hospital (SARS group) and 25 healthy personnel (control group) were included in this study. Values of blood routine test, liver and kidney function, blood lipids, blood glucose, thyroid function, tumor marker and T cell subset index were compared between two groups. Results The serum level of calcium was higher in SARS group than that of control group (mmol/L: 2.32±0.08 vs. 2.29±0.08， t=2.072， P＜ 0.05). The level of thyroxine was also higher in SARS group than that of control group (nmol/L: 119.95 ± 29.09 vs. 96.39 ± 14.26, t=3.681， P＜ 0.05), but the results were in the normal range, there was no clinical significance. The level of neuron specific enolase (NSE) was higher in SARS group than that of control group (μg/L, 10.368±3.684 vs. 3.282±1.828, t=9.012, P＜ 0.05), in which only 2 cases were slightly higher than the normal range, but did not exceed more than 1 times of the normal value. The imaging was only part of the old change, and there was no clinical significance. There were no significant differences in other results between two groups. Conclusion Virus of SARS cause no long-term effects on blood system, liver and kidney function, thyroid function and immunity in patients with SARS, and do not increase the probability of cancer.

Key words: severe acute respiratory syndrome, laboratory examination, thyroxine, neuron-specific enolase