天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (1): 56-59.doi: 10.11958/20170945

• 临床研究 • 上一篇    下一篇

电针疗法对急性脑梗死患者的临床疗效及 血清 VEGF、NSE 的影响

孙志欣，李南南，石磊△   

  1. 天津中医药大学第一附属医院（邮编 300193）
  • 收稿日期:2017-09-07 修回日期:2017-11-16 出版日期:2018-01-15 发布日期:2018-01-16
  • 通讯作者: 孙志欣 E-mail:tj_sunzx74@163.com
  • 作者简介:孙志欣（1974），女，硕士研究生，副主任医师，主要从事中医西结合治疗危重症方面研究
  • 基金资助:
    电针干预脑梗塞后神经血管单元构型调整的分子机制及远期效应研究

Effects of electroacupuncture on clinical efficacy, serum vascular endothelial growth factor and neuron specific enolase in patients with acute cerebral infarction

SUN Zhi-xin, LI Nan-nan, SHI Lei△   

  1. Department of Emergency, the First Teaching Hospital of Tianjin University of Traditional Chinese Medcine, Tianjin 300193, China
  • Received:2017-09-07 Revised:2017-11-16 Published:2018-01-15 Online:2018-01-16

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摘要： 目的 观察急性脑梗死患者电针治疗后的临床效果及血清血管内皮生长因子（VEGF）、神经元特异性烯 醇化酶（NSE）的变化。方法 选取本院神经内科 2015 年 1 月—2016 年 6 月就诊的急性脑梗死患者 96 例，按照随 机数字表法将患者分为对照组（48 例）和电针组（48 例），对照组患者给予常规治疗，电针组患者在常规治疗的基础 上给予头针和体针结合的针刺疗法，治疗 2 周。比较 2 组患者治疗后临床疗效、神经缺损功能（NIHSS）评分、血清 VEGF 和 NSE 的水平。结果 治疗 2 周后，电针组的临床有效率高于对照组（P＜0.05）。治疗 1 周和 2 周后 2 组患 者 NIHSS 评分、血清 NSE 水平较治疗前降低（P＜0.05），电针组 NIHSS 评分和血清 NSE 水平均低于对照组（P＜ 0.05）。治疗 1 周和 2 周后 2 组患者血清 VEGF 水平较治疗前升高（P＜0.05），电针组血清 VEGF 水平高于对照组 （P＜0.05）。结论 电针治疗能够促进急性脑梗死患者受损血管的再生和神经元的修复，提高患者的临床疗效，具有 一定的临床意义。

关键词: 脑梗死, 电针, 血管内皮生长因子类, 神经元特异性烯醇化酶

Abstract: Objective To evaluate the effects of electroacupuncture on clinical efficacy, changes of serum vascular endothelial growth factor (VEGF) and neuron specific enolase (NSE) in patients with acute cerebral infarction. Methods From January 2015 to June 2016, 96 patients with acute cerebral infarction were selected and randomly divided into control group (48 cases) and electroacupuncture group (48 cases). The control group was given routine treatment, and the electroacupuncture group was given acupuncture combined with scalp acupuncture and body acupuncture on the basis of routine treatment for two weeks. The clinical efficacy, NIHSS score, serum VEGF and NSE levels were evaluated in two groups of patients. Results After two weeks of treatment, the clinical effective rate was higher in electroacupuncture group than that of the control group (P＜0.05). After one week and two weeks of treatment, the NIHSS score and serum NSE level were significantly decreased in both groups of patients compared with those before treatment (P＜0.05). The NIHSS score and serum NSE level were lower in the electroacupuncture group than those in the control group (P＜0.05). After one week and two weeks of treatment, serum VEGF levels were significantly increased compared with those before treatment in the two groups (P＜0.05). The serum VEGF level was higher in electroacupuncture group than that in control group (P＜0.05). Conclusion Electroacupuncture treatment can promote the regeneration of damaged blood vessels, repair neurons and improve clinical efficacy in patients with acute cerebral infarction, which shows definite clinical significance.

Key words: brain infarction, electroacupuncture, vascular endothelial growth factors, neuron specific enolase