天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (9): 1147-1149.doi: 10.11958/20160717

• 药物临床观察 • 上一篇    下一篇

《复方多黏菌素B软膏联合碱性成纤维细胞生长因子治疗儿童深Ⅱ度烧伤创面临床疗效分析》

杨晓津 1， 方涛 2， 高秀清 2   

  1. 1 天津市血液中心（邮编 300110）；2 天津市第四中心医院医务科
  • 收稿日期:2016-07-25 修回日期:2016-08-25 出版日期:2016-09-15 发布日期:2016-09-28
  • 通讯作者: 杨晓津 E-mail:tj120yxj@163.com
  • 作者简介:杨晓津（1964）， 女， 副主任药师， 主要从事临床药学等研究

Analysis on clinical curative effect of compound polymyxin B ointment combined with basic fibroblast growth factor to treat the wound surface of deep Ⅱ degree burn of children

YANG Xiaojin1, FANG Tao2, GAO Xiuqing   

  1. 1 Tianjin Blood Center, Tianjin 300110, China; 2 Medical Department, Tianjin 4th Center Hospital
  • Received:2016-07-25 Revised:2016-08-25 Published:2016-09-15 Online:2016-09-28
  • Contact: xiao-jin YANG E-mail:tj120yxj@163.com

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摘要： 目的 观察复方多黏菌素 B 软膏联合碱性成纤维细胞生长因子（bFGF）对儿童深Ⅱ 度烫伤创面的治疗效果， 为临床治疗提供参考。 方法 选取天津市第四中心医院 2015 年 3 月—2016 年 3 月期间收治的 80 例深Ⅱ 度烫伤患儿为研究对象， 按照治疗方式分为对照组（40 例）及联合治疗组（40 例）。 对照组给予 bFGF 治疗， 联合治疗组采用复方多黏菌素 B 软膏及 bFGF 联合治疗。 比较 2 组患者烫伤创面感染率、创面愈合时间及愈合后瘢痕生成情况。结果 伤后 7、10、15 和 20 d， 联合治疗组创面感染率均较对照组降低（P < 0.05）。 联合治疗组创面愈合时间较对照组缩短［（21.53±1.33）d vs.（25.76±1.50）d， t=13.345， P < 0.01）］； 瘢痕发生情况优于对照组（U=5.077， P < 0.05）。 结论 复方多黏菌素 B 软膏联合 bFGF 治疗儿童深Ⅱ 度烫伤创面具有抗感染、加速创面愈合及预防瘢痕生成等优点，临床疗效显著。

关键词: 烧伤, 多黏菌素 B, 碱性成纤维细胞生长因子 2, 瘢痕, 伤口感染, 儿童

Abstract: Objective To observe the clinical curative effect of compound polymyxin B ointment combined with basic fibroblast growth factor (bFGF) on wound surface of deep second-degree burn in children, and provide reference for the clinical treatment. Methods Eighty cases of children patients with deep second-degree burn were included in this study, who were admitted in Tianjin 4th Center Hospital from March 2015 to March 2016. The cases were divided into control group and combined treatment group, 40 cases for each group. Wherein, the control group was treated with bFGF, the combined treatment group was received compound polymyxin B ointment and bFGF. The occurrence rate of infection of burn wound surface, wound healing time and occurrence rate of scar after healing were compared between two groups. Results There were lower infection rates on day 7, 10, 15 and 20 after burn in combined treatment group than those in control group (P< 0.05). The healing time was significantly shorter in combined treatment group than that in control group [(21.53±1.33) d vs. (25.76±1.50) d, t=13.345, P < 0.01]. The scar occurrence was significantly lessin combined group than that of control group (U=5.077， P < 0.05). Conclusion The compound polymyxin B ointment combined with bFGF show a certain effect of antiinfection, acceleration of wound surface healing and preventing the scar from generating for wound surface on deep seconddegree burn in children, which having a significant clinical curative effect.

Key words: burns, polymyxin B, basic fibroblast growth factor 2, cicatrix, wound infection, child