天津医药

天津医药 ›› 2017, Vol. 45 ›› Issue (10): 1117-1120.doi: 10.11958/20170588

• 综述 • 上一篇    

生长因子在脊髓损伤中应用的研究进展

朱旭 1,2，刘宝虎 2,3，王晶 1,2，江继鹏 2，陈江龙 2，张赛 2△   

  1. 1 天津医科大学（邮编 300070）；2 天津武警后勤学院附属医院脑科医院，武警部队脑创伤与神经疾病研究所，天津市神经创伤 修复重点实验室；3 天津中医药大学
  • 收稿日期:2017-05-22 修回日期:2017-08-07 出版日期:2017-10-15 发布日期:2017-10-13
  • 通讯作者: 朱旭 E-mail:1131352580@qq.com
  • 作者简介:朱旭（1990），男，硕士在读，主要从事脊髓损伤及颅脑创伤研究
  • 基金资助:
    国家自然科学基金青年基金;国家自然科学基金面上项目;武警后勤学院附属医院种子基金

Recent advances in the application of growth factors in spinal cord injury

ZHU Xu1,2, LIU Bao-hu2,3, WANG Jing1,2, JIANG Ji-peng2, CHEN Jiang-long2, ZHANG Sai2△   

  1. 1 Tianjin Medical University, Tianjin 300070, China；2 Department of Brain, the Affiliated Hospital of Logistics University of Chinese People’s Armed Police Forces, Key Laboratory of Nerve Trauma Repair； 3 Tianjin University of Traditional Chinese Medicine
  • Received:2017-05-22 Revised:2017-08-07 Published:2017-10-15 Online:2017-10-13

PDF (PC)

3915

摘要： 近年来，脊髓损伤发病率逐年增加，越来越受到重视。生长因子可促进神经纤维及突触的再生，在治疗脊 髓损伤和恢复神经功能方面具有重要作用。生长因子本身半衰期短，因此需要利用生长因子基因载体转染干细胞、 纳米微粒包裹生长因子或生长因子结合生物相容性支架等方法治疗脊髓损伤。随着对生长因子研究的深入，应用 单一的生长因子难以满足治疗脊髓损伤的需要，因此，探索多种生长因子的协同作用以期达到更好的治疗效果是今 后的主要研究方向。本文对脑源性神经营养因子、神经营养因子 3、神经生长因子、碱性成纤维细胞生长因子的应用 及生长因子协同治疗进展等方面进行综述，以期提高生长因子对脊髓损伤后的治疗效果。

关键词: 脊髓损伤, 胞间信号肽类和蛋白质类, 脑源性神经营养因子, 神经营养因子 3, 神经生长因子, 碱性成纤 维细胞生长因子

Abstract: The incidence of spinal cord injury is increasing year by year, and more and more attentions have been paid. Growth factors can promote the regeneration of nerve fibers and synapses, and they also play an important role in the treatment of spinal cord injury and the recovery of neurological function. The growth factor itself has a short half-life, so it is necessary to use growth factor gene vectors to transfect stem cells and nanoparticles to deliver growth factors or biocompatible scaffolds to support growth factors to treat spinal cord injuries. With the development of the research on growth factors, the application of single growth factor is difficult to meet the need of treatment to spinal cord injury. To explore the synergistic effect of various growth factors in order to achieve a better therapeutic effect is a promising research direction in the future. The purpose of this review is to summarize the therapeutic effects of growth factors on spinal cord injury including brain-derived neurotrophic factor, neurotrophic factor 3, nerve growth factor, basic fibroblast growth factor and synergy therapy of growth factors.

Key words: spinal cord injury, intercellular signaling peptides and proteins, brain- derived neurotrophic factor, neurotrophic factor-3, nerve growth factor, basic fibroblast growth factor