天津医药 ›› 2022, Vol. 50 ›› Issue (4): 439-443.doi: 10.11958/20212072

• 综述 • 上一篇    下一篇

PI3K/AKT/mTOR信号通路参与脊髓损伤后神经元自噬的研究进展

孙瑞欣 1,2,赵帅帅 1,2,申宇哲 1,2,梁家兴 1,2,杨彦玲 1,2△   

  1. 1延安大学医学院(邮编716000);2延安市神经科学重点实验室
  • 收稿日期:2021-09-08 修回日期:2021-12-21 出版日期:2022-04-15 发布日期:2022-04-15
  • 通讯作者: △通信作者及审校者 E-mail:yangyanling8889@163.com E-mail:15735011493@163.com
  • 作者简介:孙瑞欣(1997),女,硕士在读,主要从事脊髓损伤与修复方面研究。E-mail:15735011493@163.com
  • 基金资助:
    国家自然科学基金资助项目(81760235);陕西省科技厅项目社发公关项目(2019SF-041);延安大学2021年研究生教育创新计 划项目(YCX2021087)

Research progress of PI3K/AKT/mTOR signaling pathway and neuronal autophagy after spinal cord injury

SUN Ruixin1, 2, ZHAO Shuaishuai1, 2, SHEN Yuzhe1, 2, LIANG Jiaxing1, 2, YANG Yanling1, 2△ #br#   

  1. 1 School of Medicine, Yan'an University, Yan'an 716000, China; 2 Yan'an Key Laboratory of Neuroscience △Corresponding Author and Revisor E-mail: yangyanling8889@163.com
  • Received:2021-09-08 Revised:2021-12-21 Published:2022-04-15 Online:2022-04-15

摘要: PI3K/AKT/mTOR信号通路是脊髓损伤后的一条经典的自噬途径,脊髓损伤后导致的神经元细胞凋亡、轴 突脱髓鞘和炎症反应等受 PI3K/AKT/mTOR 信号通路的调控,并和神经元自噬相关。介绍脊髓损伤后 PI3K/AKT/ mTOR信号通路在神经元自噬过程中的主要作用,为进一步研究脊髓损伤提供参考。

关键词: 脊髓损伤, 自噬, PI3K/AKT/mTOR信号通路

Abstract: PI3K/AKT/mTOR signaling pathway is a classic autophagy pathway after spinal cord injury. Neuronal apoptosis, axon demyelination and inflammatory response after spinal cord injury are regulated by PI3K/AKT/mTOR signaling pathway, and are related to neuronal autophagy. This paper introduces the main role of PI3K/AKT/mTOR signaling pathway and neuronal autophagy response after spinal cord injury, hoping to provide reference for further research on spinal cord injury.

Key words: spinal cord injury, autophagy, PI3K/AKT/mTOR signaling pathway

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