天津医药

天津医药 ›› 2018, Vol. 46 ›› Issue (8): 890-893.doi: 10.11958/20180189

• 综述 • 上一篇    下一篇

胎盘来源microRNAs与子痫前期发病机制的研究进展

刘娇1， 2 ， 刘国龙2 ， 郭正晨2 ， 张云山3   

  1. 1天津医科大学总医院滨海医院妇产科 （邮编300480）； 2天津医科大学； 3天津市中心妇产科医院
  • 收稿日期:2018-02-01 修回日期:2018-04-28 出版日期:2018-08-15 发布日期:2018-08-23
  • 通讯作者: 刘娇 E-mail:liujiao@tmu.edu.cn

Progress in study on placenta-specific microRNAs and the pathogenesis of preeclampsia

LIU Jiao1,2 , LIU Guo-long2 , GUO Zheng-chen2 , ZHANG Yun-shan3   

  1. 1Department of Gynecology and Obstetrics, Binhai Hospital, Tianjin Medical University General Hospital, Tianjin 300480, China; 2 Tianjin Medical University; 3 Tianjin Central Hospital of Gynecology Obstetrics
  • Received:2018-02-01 Revised:2018-04-28 Published:2018-08-15 Online:2018-08-23

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摘要： 子痫前期是妊娠期间特有的疾病之一， 主要表现为妊娠20周后出现高血压并伴随有蛋白尿， 发病机制可能包括胎盘的异常形成及母体的炎症反应等过程。MicroRNAs是一种短链非编码RNA， 其作用是在转录水平上抑制下游靶基因的表达。一些研究提示microRNAs可作为潜在的生物学标志物评估疾病的发生发展及预后， 而胎盘来源的microRNAs的异常表达是否与子痫前期的发生、 发展密切相关仍存在争议。本文综述了胎盘来源的microRNAs与子痫前期发病机制的关系。

关键词: 子痫, 微RNAs, 胎盘, 生物学标记, 子痫前期

Abstract: Preeclampsia, one of the pregnancy specific diseases, is a leading cause of new onset hypertension and proteinuria after 20 weeks. The preeclampsia pathogenesis includes abnormal placentation and maternal inflammatory response. MicroRNAs are a kind of non-coding RNAs that induce post-transcriptional suppression of target gene expression. In biomedical research, microRNAs can be used as the potential biomarkers to assess the development and prognosis of diseases. Whether the abnormal expression of placental-derived microRNAs is closely related to the occurrence and development of preeclampsia is still controversial. This article reviews the relationship between placental microRNAs and pathogenesis of preeclampsia.

Key words: eclampsia, microRNAs, placenta, biological markers, preeclampsia