天津医药

天津医药 ›› 2020, Vol. 48 ›› Issue (12): 1192-1195.doi: 10.11958/20201986

• 临床研究 • 上一篇    下一篇

血清钙结合蛋白S100A12对肺炎支原体肺炎患儿严重程度的预测价值#br#

周四芳1，葛明盖2，张琴2，胡杨涛2，雷大伟2，蔡丽1   

  1. 1南昌市第三医院儿科（邮编330000）；2中国人民解放军第908医院皮肤科
  • 收稿日期:2020-07-13 修回日期:2020-09-15 出版日期:2020-12-15 发布日期:2020-12-13
  • 作者简介:周四芳（1975），女，博士在读，副主任医师，主要从事儿科呼吸及儿科重症方面研究
  • 基金资助:
    江西省卫生厅科技计划（20155377）

The clinical significance of serum calcium binding protein S100A12 for the severity of #br# mycoplasma pneumonia in children #br#

ZHOU Si-fang1, GE Ming-gai2, ZHANG Qin2, HU Yang-tao2, LEI Da-wei2, CAI Li1   

  1. 1 Department of Pediatrics, the Third Hospital of Nanchang, Nanchang 330000, China; 2 Department of 
    Dermatology, the 908 Hospital of PLA
  • Received:2020-07-13 Revised:2020-09-15 Published:2020-12-15 Online:2020-12-13

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摘要： 目的　探讨血清钙结合蛋白S100A12预测肺炎支原体肺炎（MPP）患儿严重程度的临床意义。方法　选取2018年1月—2019年6月南昌市第三医院儿科收治的100例MPP患儿，根据病情严重程度分为MPP组60例和重症MPP（SMPP）组40例，另选取同期在我院体检健康儿童20例作为对照组。采集血清标本后检测白细胞计数（WBC）、中性粒细胞比例（N）、淋巴细胞比例（L）、C反应蛋白（CRP）水平，采用酶联免疫吸附法检测血清钙结合蛋白S100A12水平。分别比较MPP组和SMPP组急性期及恢复期S100A12的差异，分析S100A12与MPP患儿严重程度的相关性，受试者工作特征（ROC）曲线分析S100A12对重症MPP的预测价值。结果　与对照组比较，MPP组和SMPP组急性期患儿血清S100A12水平显著升高（P＜0.01）；且SMPP组急性期血清S100A12水平较MPP组显著升高（P＜0.05）；MPP组和SMPP组恢复期和对照组血清S100A12水平差异无统计学意义（P＞0.05）。相关性分析结果显示，S100A12与MPP患儿严重程度呈正相关（rs=0.824，P＜0.01）。ROC曲线分析结果显示S100A12预测SMPP的曲线下面积分别为0.916（95%CI：0.843~0.962），最佳临界值为827.64 μg/L，此时敏感度为95.00%，特异度为83.33%。结论　血清S100A12水平升高可预测儿童MPP的严重程度。

关键词: 肺炎, 支原体, S100A12蛋白质, 曲线下面积, 严重程度, 临床价值

Abstract: Objective　To investigate the clinical significance of serum calcium-binding protein S100A12 for the severity of mycoplasma pneumoniae pneumonia (MPP) in children. Methods　A total of 100 cases of MPP admitted to the department of pediatrics of the third hospital of Nanchang were selected from January 2018 to June 2019. According to the severity of the disease, they were divided into mild MPP group (n=60) and severe MPP (SMPP, n=40) group. Twenty healthy children examined in our hospital during the same period were selected as the control group. Serum samples were collected.  White blood cell count (WBC), neutrophils (N%), lymphocytes (L) and C-reactive protein (CRP) levels were detected. Serum levels of calcium-binding protein S100A12 were detected by ELISA. The differences of S100A12 in the acute and recovery stages were compared between MPP group and SMPP group. The correlation between S100A12 and the severity of MPP wasanalyzed. The ROC curve was used to analyze the clinical value of S100A12 in predicting severe MPP. Results　compared with the control group, serum levels of S100A12 were significantly increased in the acute phase of MPP group and SMPP group (P＜0.01). The serum level of S100A12 in the acute phase was significantly higher in SMPP group than that of MPP group (P＜0.05). There were no significant differences in the serum levels of S100A12 in the recovery phase between MPP and SMPP groups and control group (P＞0.05). Correlation analysis showed that S100A12 was positively correlated with the severity of MPP (rs=0.824, P＜0.01). ROC curve analysis showed that the area under the curve of S100A12 was 0.916 (95%CI: 0.843-0.962), the optimal threshold was 827.64 μg/L, the sensitivity was 95.00% and the specificity was 83.33%. Conclusion　The elevated S100A12 level can predict the severity of MPP in children.

Key words: pneumonia, mycoplasma, S100A12 protein, area under curve, severity, clinical significance

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