天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (1): 107-112.doi: 10.11958/20202154

• 综述 • 上一篇    

植物来源天然小分子化合物防治骨质疏松症的研究进展

魏金星，王诺鑫，罗熠，许艳，肖建辉△   

  1. 遵义医科大学附属医院，遵义市医药生物技术重点实验室&贵州省转化医学工程研究中心（邮编563003）
      作者简介：魏金星（1994），女，硕士在读，主要从事干细胞分化方面研究
  • 收稿日期:2020-07-27 修回日期:2020-09-02 出版日期:2021-01-15 发布日期:2021-01-15
  • 通讯作者: 肖建辉 E-mail:jhxiao@zmu.edu.cn
  • 基金资助:
    国家自然科学基金资助项目（81660363）；贵州省高层次创新性人才支持计划（黔科合人才［2015］4028号）；贵州省科技基金重点项目（黔科合［2017］1422号）

Research progress on prevention and treatment of osteoporosis with plant-derived natural small molecular compounds

WEI Jin-xing, WANG Nuo-xin, LUO Yi, XU Yan, XIAO Jian-hui△   

  1. Zunyi Municipal Key Laboratory of Medicial Biotechnology & Guizhou Engineering Technology Research Center for Translational Medicine, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China
  • Received:2020-07-27 Revised:2020-09-02 Published:2021-01-15 Online:2021-01-15

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摘要： 摘要：骨质疏松症是一种以骨量减少、骨质量下降和骨微结构退化为特征的全身性骨病，其病因主要是骨代谢障碍，即破骨细胞的过度形成，导致骨吸收增加和成骨形成不足所致。传统中草药等植物来源的天然小分子化合物由于来源丰富、结构多样、不良反应少等特性可作为预防和治疗骨质疏松症的替代药物。本文综述了近年来发现的具有骨保护作用的植物来源的天然小分子化合物的研究进展，以期为预防和治疗骨质疏松药物的开发提供新思路。

关键词: 骨质疏松, 成骨细胞, 破骨细胞, 植物药, 天然小分子化合物, 成骨分化

Abstract: Abstract: Osteoporosis is a systemic metabolic chronic bone disease characterized by reduced bone mass, decreased bone quality and degraded bone microstructure. It is mainly caused by bone metabolism disorder, that is, the increased bone resorption and insufficient bone formation resulted from the excessive formation of osteoclasts. Natural small-molecule compounds derived from traditional Chinese herbs and other plants can be used as alternative medicine for the prevention and treatment of osteoporosis due to their advantages such as rich sources, diverse structures and few adverse effects. This article outlines the research progress on plant-derived natural small molecule compounds against osteoporosis in recent years, with a view to providing new ideas for the development of drugs and the prevention and treatment of osteoporosis.

Key words: osteoporosis, osteoblasts, osteoclasts, herbal drugs, natural small molecule compounds, osteogenic differentiation