天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (7): 778-784.doi: 10.11958/20210352

• 综述 • 上一篇    

主动脉瓣膜间质细胞分化机制研究进展

由万宁，赖永洁   

  1. 1遵义医科大学珠海校区/贵州省免疫学研究生创新研究基地（邮编519041）；2遵义医科大学珠海校区免疫学与病原生物学教 研室
  • 收稿日期:2021-02-07 修回日期:2021-03-01 出版日期:2021-07-15 发布日期:2021-07-12
  • 作者简介:由万宁（1997），女，硕士在读，主要从事瓣膜间质细胞的分化机制研究。E-mail：915799247@qq.com
  • 基金资助:
    国家自然科学基金青年基金项目（81700341）；贵州省自然科学基金（黔科合基础［2020］1Y297）；贵州省教育厅科学基金（黔教合KY字［2017］184）

Research progress on the differentiation mechanism of aortic valve interstitial cells

YOU Wan-ning, LAI Yong-jie   

  1. 1 Zhuhai Campus of Zunyi Medical University/Education and Innovation Base for Immunology Graduate Students in Guizhou Province, Zhuhai 519041, China; 2 Department of Immunology and Pathogenic Biology, Zhuhai Campus of Zunyi Medical University
  • Received:2021-02-07 Revised:2021-03-01 Published:2021-07-15 Online:2021-07-12

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摘要： 瓣膜纤维化或钙化是瓣膜性心脏病（VHD）的两大重要病理表现，其中瓣膜间质细胞（VICs）由成纤维细胞样表型分化为肌成纤维细胞表型或成骨细胞表型，是瓣膜发生早期病理改变的关键环节。VHD多累及主动脉瓣，近年来有关VICs分化的研究多聚焦于主动脉瓣来源细胞。本文就主动脉瓣VICs分化的最新研究进展予以综述，旨在为VHD的防治研究提供更为全面的参考。

关键词: 心脏瓣膜疾病, 主动脉瓣, 纤维化, 细胞分化, 钙化, 瓣膜间质细胞

Abstract: Heart valve fibrosis and calcification are two impartant pathological changes of valvular heart diseases (VHD). The differentiation of valve interstitial cells (VICs) from fibroblast like phenotype to myofibroblast like phenotype or osteoblast like phenotype is considered as the milestone event of the early pathological changes of VHD. Aortic valves are the major target organs in VHD development. In recent years, studies on the differentiation of VICs were mainly focused on aortic valve derived cells. In this paper we summarize the recent findings on the differentiation of VICs, aim to provide a comprehensive background for the development of novel prevention and treatment strategies for VHD.

Key words: heart valve diseases, aortic valve, fibrosis, cell differentiation, calcification, valve interstitial cell