天津医药

天津医药 ›› 2021, Vol. 49 ›› Issue (10): 1111-1115.doi: 10.11958/20210895

• 综述 • 上一篇    下一篇

长链非编码RNA与先天腭裂畸形的关系研究进展

唐璟，宋庆高
  

  1. 遵义医科大学附属口腔医院口腔颌面外科（邮编563000）

  • 收稿日期:2021-04-19 修回日期:2021-07-09 出版日期:2021-10-15 发布日期:2021-10-15
  • 通讯作者: 唐璟 E-mail:798674180@qq.com
  • 基金资助:
    国家自然科学基金项目

Research progress on the relationship between long non-coding RNA and congenital cleft palate

TANG Jing, SONG Qing-gao #br#   

  1. Oral and Maxillofacial Surgery, Stomatological Hospital of Zunyi Medical University, Zunyi 563000, China
  • Received:2021-04-19 Revised:2021-07-09 Published:2021-10-15 Online:2021-10-15
  • Contact: Jing TANG E-mail:798674180@qq.com

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摘要： 腭裂是颌面部常见的先天性发育畸形。腭部的发育有着严密的规律和精确的时空顺序，对其发育过程的 任何微小干扰都可能导致腭裂的发生。长链非编码RNA（lncRNA）可从多个层面调控细胞生物学行为，与腭裂的发 生发展密切相关。就lncRNA调控细胞分化增殖、自噬和凋亡以及上皮-间充质转化的机制等方面进行介绍，并初步 总结现阶段已知的腭裂中lncRNA-miRNA调控轴，以期为腭裂畸形的病因研究提供新的参考和视角。

关键词: 腭裂, 基因表达调控, RNA, 长链非编码, 微RNAs, 竞争性内源RNA, lncRNA-miRNA调节轴

Abstract: Cleft palate is a common congenital developmental malformation of the maxillofacial region. The development of palate has strict pattern and precise spatial and temporal sequence, and any small disturbance to its developmental process may lead to cleft palate. Several studies have shown that long non-coding RNAs (lncRNA) can regulate cell biological behavior at multiple levels and are closely related to the development of cleft palate. Therefore, in this paper, we introduced the mechanisms of lncRNA regulating cell differentiation, proliferation, autophagy, apoptosis and epithelial-mesenchymal transition, and preliminarily summarized the currently known lncRNA-miRNA regulatory axis in cleft palate in order to provide a new reference and perspective for the etiological study of cleft palate malformation.

Key words: cleft palate, gene expression regulation, RNA, long non-coding, microRNAs, competitive endogenous RNA, lncRNA-miRNA regulating axis