昆虫抗菌肽抗炎活性及基于信号通路抗炎机制的研究进展

doi:10.11958/20212862

天津医药 ›› 2022, Vol. 50 ›› Issue (9): 1002-1008.doi: 10.11958/20212862

• 综述 • 上一篇

昆虫抗菌肽抗炎活性及基于信号通路抗炎机制的研究进展

崔会程(), 夏嫱()

遵义医科大学珠海校区/贵州省免疫学研究生创新研究基地（邮编519041）

收稿日期:2021-12-31 修回日期:2022-04-28 出版日期:2022-09-15 发布日期:2022-09-05
通讯作者: 夏嫱 E-mail:782198846@qq.com;xiaqiang1973@126.com
作者简介:崔会程（1993）,男,硕士在读,主要从事昆虫抗菌肽抗炎功能方面研究。E-mail： 782198846@qq.com
基金资助:
国家自然科学基金项目(32060127);贵州省科技计划项目(黔科合基础-ZK[2021]一般101);遵义医科大学学术新苗培养及创新探索专项项目(黔科合平台人才[2017]5733-069)

Research progress in anti-inflammatory activity of insect antimicrobial peptides and anti-inflammatory mechanism based on signal pathway

CUI Huicheng(), XIA Qiang()

Zhuhai Campus of Zunyi Medical University/ Education and Innovation Base for Immunology Graduate Students in Guizhou Province, Zhuhai 519041, China

Received:2021-12-31 Revised:2022-04-28 Published:2022-09-15 Online:2022-09-05
Contact: XIA Qiang E-mail:782198846@qq.com;xiaqiang1973@126.com

崔会程, 夏嫱. 昆虫抗菌肽抗炎活性及基于信号通路抗炎机制的研究进展[J]. 天津医药, 2022, 50(9): 1002-1008.

CUI Huicheng, XIA Qiang. Research progress in anti-inflammatory activity of insect antimicrobial peptides and anti-inflammatory mechanism based on signal pathway[J]. Tianjin Medical Journal, 2022, 50(9): 1002-1008.

摘要/Abstract

摘要：

昆虫抗菌肽是昆虫为抵御外界病原微生物感染产生的免疫活性物质的总称,其优异的抗炎活性使其具有广阔的应用前景。综述了不同种类昆虫抗菌肽的抗炎活性及可能涉及的信号通路,介绍了昆虫抗菌肽临床研究现状,以期为昆虫抗菌肽的应用研究提供文献参考。

关键词: 抗炎药（中药）, 抗菌肽, 昆虫, 信号通路, 抗炎活性

Abstract:

Insect antimicrobial peptides are the general name of immune active substances produced by insects to resist the infection of external pathogenic microorganisms. Their excellent anti-inflammatory activity makes them have broad application prospects. In this paper, the anti-inflammatory activities and their possible signaling pathways of different insect antimicrobial peptides were reviewed, and the current status of clinical research on insect antimicrobial peptides was introduced, in order to provide references for the application of insect antimicrobial peptides.

Key words: anti-inflammatory drugs (TCD), antimicrobial peptide, insect, signaling pathway, anti-inflammatory activity

中图分类号:

R392.9

参考文献 61

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昆虫抗菌肽抗炎活性及基于信号通路抗炎机制的研究进展

Research progress in anti-inflammatory activity of insect antimicrobial peptides and anti-inflammatory mechanism based on signal pathway

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