天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (2): 253-256.doi: 10.11958/58917

• 综述 • 上一篇    

嵌合抗原受体 T 细胞治疗原发性肿瘤的优势与研究进展

张巍 1， 闫丹丹 2， 高莉 2， 邵明亮 1， 闫会敏 1△   

  1. 1石家庄市第五医院研究所 （邮编 050021）； 2河北师范大学
  • 收稿日期:2015-05-11 修回日期:2015-09-29 出版日期:2016-02-15 发布日期:2016-02-15
  • 通讯作者: △通讯作者 E-mail： yanhm_2538@163.com E-mail:viviast@163.com
  • 基金资助:
    河北省卫生厅科研项目 （ZD20140735）

The advantages and research progress of T cells of the chimeric antigen receptor in the treatment of primary tumors

ZHANG Wei1, YAN Dandan2, GAO Li2, SHAO Mingliang1, YAN Huimin1△   

  1. 1 Institute of Liver Diseases, Shijiazhuang Fifth Hospital, Shijiazhuang 050021, China; 2 Hebei Normal University
  • Received:2015-05-11 Revised:2015-09-29 Published:2016-02-15 Online:2016-02-15
  • Contact: △Corresponding Author E-mail: yanhm_2538@163.com E-mail:viviast@163.com

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摘要： 嵌合抗原受体 （Car） T 细胞因不仅具有较强特异性识别肿瘤抗原的特性， 还具有杀伤性、 亲和力高等优点， 因而受到较多的关注。尽管其在抗肿瘤方面发挥了很多优势， 但是仍存在不足之处， 需要进一步优化来提高其临床 应用的安全性。本研究对 Car T 细胞结构及其生物功能、 治疗流程、 应用进展以及应用风险进行综述， 为进一步在临 床开展 Car T 免疫治疗提供参考。

关键词: 嵌合抗原受体 T, 细胞治疗, 肿瘤, 综述

Abstract: Chimeric antigen receptor (Car) T cells, not only have the characteristics of strong specific recognition of tumor antigens, but also have destruction and high affinity advantages, thus receiving more attention. Although it has played a lot of advantages in anti-tumor, it still has some shortcomings, which needs to be further optimized to improve the safety of its clinical application. In this study, The cell structure and biological function, treatment process, application development and application risk of Car T cells are reviewed, which provide references for further clinical immunotherapy of Car T.

Key words: Car T, cell therapy, neoplasms, review