天津医药

天津医药 ›› 2016, Vol. 44 ›› Issue (2): 247-250.doi: 10.11958/59124

• 综述 • 上一篇    下一篇

miRNAs 以非细胞自主机制参与肿瘤微环境调节的研究进展

郭金满， 谭超△， 胡火军， 谭园   

  1. 湖北宜昌， 三峡大学第一临床医学院 （邮编 443002）
  • 收稿日期:2015-06-23 修回日期:2015-09-18 出版日期:2016-02-15 发布日期:2016-02-15
  • 通讯作者: △通讯作者 E-mail:yczxyytanchao@sina.com E-mail:yczxyytanchao@sina.com
  • 基金资助:
    湖北省自然科学基金资助项目 （2014CFB307）

Research progress of MicroRNAs involved in the tumor microenvironment regulation in non-cell-autonomous mechanisms

GUO Jinman, TAN Chao△, HU Huojun, TAN Yuan   

  1. The First Clinical Medical College, China Three Gorges University, Yichang 443002, China
  • Received:2015-06-23 Revised:2015-09-18 Published:2016-02-15 Online:2016-02-15
  • Contact: △Corresponding Author E-mail: yczxyytanchao@sina.com E-mail:yczxyytanchao@sina.com
  • Supported by:
    Hubei province natural science foundation of China

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摘要： 肿瘤微环境是肿瘤发生发展过程中所处的内环境 , 由多种细胞及细胞外基质组成， 是肿瘤形成、 转移以及耐药的关键因素。对肿瘤微环境的调控将成为治疗肿瘤的靶点之一。MicroRNAs（miRNAs） 是一类 21~25 个核苷酸的非编码单链 RNA， 主要参与基因的表达调控。近年来， 随着非细胞自主抑癌机制的提出， 使 miRNAs 对肿瘤微环境的调控受到了极大关注。本文主要阐述 miRNAs 通过非细胞自主机制对肿瘤微环境的影响， 为对肿瘤微环境的深入研究以及肿瘤治疗提供参考。

关键词: 微 RNAs, 肿瘤, 微环境, 非细胞自主性, 基因表达调控, 免疫, 细胞, 综述

Abstract: As an internal environment of tumor occurrence, tumor microenvironment is composed of a variety of cells and extracellular matrix, and plays a crucial role in tumor formation, transfer and resistance to drugs. The regulation of tumor microenvironment will be a potential target to control the cancer. MicroRNAs (miRNAs) are a kind of 21 to 25 nucleotides single-stranded RNA, and are mainly involved in regulating gene expression. Recently, with the suggestion of cellular autonomous tumor inhibition mechanism, the regulation of tumor microenvironment by miRNAs has received great attention. This review summarizes recent findings on the non-cell-autonomous mechanisms of miRNAs-mediated regulation of tumor micro⁃ environments, which provides foundations and perspective on the design of therapeutic interventions.

Key words: microRNAs, tumor, microenvironment, non-cell-autonomous function, gene expression regulation, immunity, cellular, review