天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (2): 170-174.doi: 10.11958/j.issn.0253-9896.2015.02.015

• 临床研究 • 上一篇    下一篇

FOXQ1 和E-cadherin 在食管鳞状细胞癌中的表达及临床意义

于海峰 1 ,张逊 2△,徐美林 3 ,王菁 3 ,卢喜科 2   

  1. 1天津医科大学研究生院 （邮编300070）； 2天津市胸科医院胸外科， 3病理科5. 天津市胸科医院
  • 收稿日期:2014-08-15 修回日期:2014-10-20 出版日期:2015-02-15 发布日期:2015-02-27
  • 通讯作者: 张逊 E-mail:zhangxun69@163.com

Expression levels and clinical significance of FOXQ1 and E-cadherin in esophageal squamous cell carcinoma

  • Received:2014-08-15 Revised:2014-10-20 Published:2015-02-15 Online:2015-02-27

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摘要： 摘要： 目的 探讨叉头框蛋白 Q1 （FOXQ1） 和 E-钙黏蛋白 （E-cadherin） 在食管鳞状细胞癌 （ESCC） 中的表达及临床意义。方法 采用免疫组织化学法检测 42 例 ESCC 组织 （ESCC 组） 及其癌旁正常食管鳞状上皮组织 （正常组） 中 FOXQ1 和 E-cadherin 的表达情况， 分析其表达与患者临床病理特征及预后的关系。结果 ESCC 组 FOXQ1 的阳性表达率高于正常组 （64.29% vs 28.57%， χ2 =5.384， P＜0.05）， E-cadherin 的阳性表达率低于正常组 （52.38% vs 90.48%， χ2 =7.691， P＜0.05）。FOXQ1 的表达强度在不同 TNM 分期及不同淋巴结转移情况间的差异有统计学意义， E-cad⁃ herin 的表达强度在不同浸润深度、 分化程度、 TNM 分期和淋巴结转移情况间的差异有统计学意义。ESCC 组织中 FOXQ1 和 E-cadherin 的表达呈负相关（r =-0.412， P<0.05）。FOXQ1 高表达者的 5 年生存率低于低表达者（18.52% vs 66.67%， χ2 =9.737， P < 0.05）， E-cadherin 高表达者的 5 年生存率高于低表达者 （59.09% vs 10.00%， χ2 = 10.996， P < 0.05）。COX 比例风险回归模型分析结果显示， FOXQ1 高表达、 E-cadherin 低表达、 有淋巴结转移是影响 ESCC 患者预后的独立危险因素。结论 FOXQ1 和 E-cadherin 在 ESCC 组织中的表达呈现较好的相关性，联合检测两者的表达对于 ESCC 患者的预后判断及指导治疗具有一定的临床价值。

关键词: 食管肿瘤, 癌,鳞状细胞, 钙黏着糖蛋白类, 预后, 免疫组织化学, 叉头框蛋白 Q1, E-钙黏蛋白

Abstract: Abstract:Objective To investigate the expression levels and clinical significance of (forkhead box Q1) FOXQ1 and E-cadherin in esophageal squamous cell carcinoma (ESCC). Methods Expression levels of FOXQ1 and E-cadherin were in ESCC tissues (ESCC group, n=42) and adjacent normal esophageal tissues (control group, n=42) were detected using im⁃ munohistochemistry. Correlations of FOXQ1 and E-cadherin expressions with clinical pathological parameters and progno⁃ sis were analyzed between two groups. Results The expression level of FOXQ1 was significantly higher in ESCC group than that in control group（64.29% vs 28.57%， χ2 =5.384， P＜0.05） . The expression level of E-cadherin was significantly lower in ESCC group than that incontrol group （52.38% vs 90.48%， χ2 =7.691， P＜0.05） . There were significant differences in FOXQ1 expressions between different TNM stages and whether lymph node metastasis is involved within ESCC group. There were significant differences in expression of E-cadherin between different tumor differentiation, depth of invasion, TNM stage and whether lymph node metastasis is involved within ESCC group. The expression of FOXQ1 was negatively cor⁃ related with E-cadherin in ESCC (r =-0.412, P < 0.05). The 5-year survival rates were significantly lower with high expres⁃ sion of FOXQ1 or with low expression of FOXQ1 （18.52% vs 66.67%， χ2 =9.737， P < 0.05） . The 5-year survival rates were significantly higher with high expression of E-cadherinor low expression of E-cadherin （59.09% vs 10.00%， χ2 =10.996， P < 0.05） . A multivariate Cox's proportional hazard regression analysis indicated that high FOXQ1 expression, low E-cadherin expression and lymph node metastasis were independent prognostic factors for ESCC. Conclusion The expression of FOXQ1 and E-cadherin showed a good correlation with ESCC. And examining expressions of both FOXQ1 and E-cadherin in ESCC may have practical values in estimating the prognosis of ESCC and directing future treatment .

Key words: esophageal neoplasms, carcinoma, squamous cell, cadherins, prognosis, immunohistochemistry, forkhead box Q1, E-cadherin