天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (8): 876-879.doi: 10.11958/j.issn.0253-9896.2015.08.012

• 临床研究 • 上一篇    下一篇

Galectin-3 和β-catenin 在子宫内膜异位症中的表达及二者的相关性

石亚楠，黄河玲，郭瑞峰，刘艺   

  1. 1河北北方学院（邮编075000）；2解放军第二五二医院
  • 收稿日期:2014-12-10 修回日期:2015-03-09 出版日期:2015-08-15 发布日期:2015-08-15
  • 通讯作者: 黄河玲 E-mail:934632762@qq.com
  • 作者简介:石亚楠（1988），女，硕士在读，主要从事妇科肿瘤方向的研究

The expressions of Galectin-3 and β-catenin and their correlation studies in endometriosis

SHI Ya’nan，HUANG Heling,GUO Ruifeng，LIU Yi   

  1. 1 HeBei North University，Zhangjiakou 075000，China；2 The People′s Liberation Army 252 Hospital
  • Received:2014-12-10 Revised:2015-03-09 Published:2015-08-15 Online:2015-08-15

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摘要： 目的探讨半乳糖凝集素-3（Galectin-3）和β连环素（β-catenin）在子宫内膜异位症（EMs）患者的异位内膜和在位内膜中的表达及其在EMs 发病中的作用及关系。方法应用免疫组织化学法检测34 例EMs 患者（EMs 组）的异位内膜和在位内膜及30 例非子宫内膜异位症（正常对照组）的在位子宫内膜中的半乳糖凝集素-3 和β连环素的表达情况，并分析二者的相关性。结果半乳糖凝集素-3 在EMs 组异位内膜、在位内膜及正常对照组在位内膜的阳性表达率分别为88.2%、85.3%、50.0%；β连环素在上述3 组的异常表达率分别为55.9%、52.9%、26.7%。EMs 异位内膜组、在位内膜组的半乳糖凝集素-3 的阳性表达率和β连环素的异常表达率均高于正常对照组（P＜0.05）。EMs 组异位内膜、在位内膜中的半乳糖凝集素-3 的阳性表达和β连环素的异常表达呈正相关（rs 分别为0.512、0.428，P＜ 0.01）。结论半乳糖凝集素-3 和β连环素可能在EMs 的发病中共同起着重要作用。

关键词: 半乳糖凝集素3, β连环素, 子宫内膜异位症, 免疫组织化学

Abstract: Objective To investigate the expressions and mutual relationship of Galectin-3 and β-catenin in endome⁃ triosis (EM). Methods Immunohistochemistry was used to detect expression levels of Galectin-3 and β-catenin and their mutual relationship in expression was also examined. Samples were collected from ectopic endometrium of patients with en⁃ dometriosis (ectopic endometrium group, n=34), eutopic endometrium of patients with endometriosis (eutopic endometrium group, n=34) and normal endometrium from people without endometriosis (control group, n=30). Results The expressions of Galectin-3 were seen in 88.2%, 85.3%, 50.0% of cases in ectopic endometrium group, eutopic endometrium group and control group respectively. On the other hand, the expression of β-catenin were seen in 55.9%, 52.9%, 26.7% of cases in ecto⁃ pic endometrium group, eutopic endometrium group and control group respectively. In EMs patients, the expression of Galec⁃ tin-3 and β-catenin were significantly higher in ectopic endometrium and eutopic endometrium than those in normal endome⁃ trium group（P＜0.05）. Expression of Galectin-3 was positive correlated with expression of β-catenin（rs=0.512, 0.428, P＜ 0.01）. Conclusion Galectin-3 and β-catenin may play important roles synergistically in the pathogenesis of endometriosis.

Key words: Galectin 3, beta catenin, endometriosis, immunohistochemistry