天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (8): 950-953.doi: 10.11958/j.issn.0253-9896.2015.08.033

• 综述 • 上一篇    下一篇

基因芯片技术在肾病综合征研究中的应用前景

张碧丽，郁晓腾   

  1. 天津市儿童医院肾内科
  • 收稿日期:2015-03-13 修回日期:2015-04-12 出版日期:2015-08-15 发布日期:2015-08-15
  • 作者简介:张碧丽（1959），女，主任医师，硕士生导师，主要从事小儿内科肾脏疾病研究
  • 基金资助:
    天津市应用基础与前沿技术研究计划项目（13JCYBJC22300）

Application of gene chip in nephritic syndrome research

ZHANG Bili，YU Xiaoteng   

  1. Department of Nephrology, The Children′s Hospital of Tianjin, Tianjin 300074, China
  • Received:2015-03-13 Revised:2015-04-12 Published:2015-08-15 Online:2015-08-15

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摘要： 肾病综合征是儿童常见的肾脏疾病，目前其发病机制尚未完全阐明。近年来基因芯片技术日渐成熟，广泛应用于多个领域。应用基因芯片技术可以从基因水平分析肾病综合征的致病机制和药物治疗的作用靶点。本文重点介绍基因芯片技术在肾病综合征中的应用现状及前景。

关键词: 寡核苷酸序列分析, 肾病综合征, 综述, 基因芯片

Abstract: Nephrotic syndrome is a common kidney disease in childhood. Its pathogenesis has not been fully elucidat⁃ ed. In recent years, gene chip is maturing and widely used in many fields. Its application in nephrotic syndrome could pro⁃ vide important information of its pathogenesis and treatment target at gene level. This article reveiwed the current application of the gene chip technology and its prospects in the nephrotic syndrome.

Key words: oligonucleotide array sequence analysis, nephrotic syndrome, review, gene chip