天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (9): 1012-1014.doi: 10.11958/j.issn.0253-9896.2015.09.015

• 临床研究 • 上一篇    下一篇

血清和卵泡液中的NGF水平与PCOS的相关性研究

王春艳1,樊桂玲2,易建平2   

  1. 1. 迁安市妇幼保健院
    2. 唐山市妇幼保健院
  • 收稿日期:2014-11-26 修回日期:2015-04-28 出版日期:2015-09-15 发布日期:2015-09-15
  • 通讯作者: 王春艳 E-mail:13363378579@163.com
  • 作者简介:王春艳 （1979）， 女， 研究生， 硕士学位， 主治医师， 主要从事生殖内分泌方面研究

The relationship between NGF in serum and follicular fluid and polycystic ovary syndrome

WANG Chunyan1#br# , FAN Guiling2#br# , YI Jianping2   

  1. 1 Qianan Maternal and Child Health Hospital, Tangshan 064400, China; 2 Maternal and Child Health Hospital of Tangshan
  • Received:2014-11-26 Revised:2015-04-28 Published:2015-09-15 Online:2015-09-15

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摘要： 摘要： 目的 检测多囊卵巢综合征 （PCOS） 患者血清与卵泡液中神经生长因子 （NGF） 水平， 探讨 NGF 水平与 PCOS 发生的相关性以及对 PCOS 患者助孕结局的影响。方法 收集 2011 年 12 月—2012 年 11 月在唐山市妇幼保健院生殖遗传科行体外受精-胚胎移植 （IVF-ET） 的 PCOS 患者 65 例及同期因输卵管因素行 IVF-ET 的非 PCOS 患者 31 例作为对照组。采用 ELISA 检测 96 例患者绒毛膜促性腺激素 （HCG） 注射日血清和取卵日卵泡液中 NGF 的水平。比较 PCOS 组与正常对照组妊娠与未妊娠患者血清与卵泡液中 NGF 的水平。结果 PCOS 患者血清[ （14.38± 0.42） ng/L]及卵泡液[ （9.61±0.49） ng/L]中的 NGF 水平明显高于正常对照组[ （11.39±0.38） ng/L、 (7.55±0.40） ng/L]； PCOS 患者妊娠组血清[ （14.22±0.35） ng/L]和卵泡液[ （9.30±0.31） ng/L]中的 NGF 水平低于未妊娠组[ （14.51±0.43） ng/L、（9.86±0.46） ng/L]， 差异有统计学意义 （均 P＜0.01）。结论 PCOS 患者血清和卵泡液内存在 NGF 水平高表达， 血清和卵泡液内过高的 NGF 水平可能不利于 PCOS 患者成功妊娠。

关键词: 多囊卵巢综合征, 神经生长因子, 血清, 卵泡液

Abstract: Objective To investigate the relationship of nerve growth factor (NGF) between serum and follicular fluid in patients with polycystic ovary syndrome (PCOS), and its effect on pregnancy outcomes. Methods From December 2011 to November 2012, 65 PCOS patients suffered with in vitro fertilization - embryo transfer (IVF - ET) were included in PCOS group and 31 non-PCOS patients with IVF - ET were used as control group. The expressions of NGF in serum and follicular fluid were detected by ELISA on the injection day of chorionic gonadotropin (HCG). The expression levels of NGF in serum and follicular fluid were compared between PCOS group and control group. Results The NGF levels in serum[(14.38±0.42) ng/L] and follicular fluid[(9.61±0.49)ng/L] were significantly higher in PCOS group than those of control group[(11.39±0.38) ng/L and (7.55±0.40)ng/L]. In PCOS group, NGF levels in serum [(14.22±0.35)ng/L] and follicular fluid [(9.30±0.31)ng/L] were significantly lower in pregnant group than those of non-pregnant group[(14.51±0.43)ng/L, (9.86±0.46)ng/L, P＜0.01]. Conclusion The increased levels of NGF in serum and follicular fluid of PCOS patients contribute to the pathogenesis of PCOS. The high expression of NGF in serum and follicular fluid may be harmful to pregnancy in PCOS patients.

Key words: polycystic ovary syndrome, nerve growth factor, serum, follicular fluid