天津医药

天津医药 ›› 2015, Vol. 43 ›› Issue (9): 1073-1078.doi: 10.11958/j.issn.0253-9896.2015.09.033

• 循证医学 • 上一篇    下一篇

儿童急性下呼吸道感染相关危险因素的meta分析

付卓1，万莉雅1△， 徐勇胜1，郑跃杰2   

  1. 1. 天津市儿童医院
    2. 遵义医学院深圳儿童医院
  • 收稿日期:2015-01-23 修回日期:2015-05-12 出版日期:2015-09-15 发布日期:2015-09-15
  • 通讯作者: 万莉雅 E-mail:wanliya_1209@163.com E-mail:fuzhuoertong@163.com
  • 作者简介:付卓 （1977）， 女， 硕士研究生， 主要从事小儿呼吸内科方面研究

Meta- analysis of risk factors of severe acute lower respiratory infections in children

FU Zhuo,WAN Liya,XU Yongsheng,ZHENG Yuejie    

  1. 1 Tianjin Children’ s Hospital, Tianjin 300134, China; 2 Zunyi Medical University, Shenzhen Children’ s Hospital
  • Received:2015-01-23 Revised:2015-05-12 Published:2015-09-15 Online:2015-09-15
  • Contact: △Corresponding Author E-mail:wanliya_1209@163.com E-mail:fuzhuoertong@163.com

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摘要： 摘要： 目的 探讨儿童急性下呼吸道感染 （ALRI） 的相关危险因素， 为其防治提供科学依据。方法 计算机检索 Med、 Databases-Medline (Ovid)、 Embase、 CINAHL 和 Global Health Library、 中国知网 （CNKI）、 维普 （VIP） 和万方数库， 查找有关儿童急性下呼吸道感染的危险因素的期刊与论文， 检索时限均为 1990 年 1 月—2014 年 12 月。根据献纳入与排除标准， 由 2 位评价员独立进行文献资料的筛选与提取并质量评价后， 采用 Stata 11.0 软件进行 Meta 析。结果 对纳入的 27 篇文献进行 Meta 分析， 结果显示， 低出生体质量、 缺乏充足的母乳喂养、 房间拥挤、 室内空污染、 营养不良、 处于吸烟环境 （或孕妇吸烟） 和 HIV 接触史 （未感染情况） 与 ALRI 密切相关。结论 上述 7 种危因素在ALRI 进程中起重要作用， 还需进一步研究发现其他潜在的危险因素， 以降低儿童 ALRI 的可能性。关键词： 呼吸道感染； 急性病； 危险因素； Meta 分析； 儿童

关键词: 呼吸道感染, 急性病, 危险因素, Meta 分析, 儿童

Abstract: Abstract:Objective To identify the risk factors for severe acute lower respiratory infections (ALRI) in children and to provide scientific basis for prevention and treatment of ALRI. Methods Several databases including Pubmed, Databases- Medline (Ovid), Embase, CINAHL and Global Health Library, CNKI, VIP and Wanfang Date were searched (1990.1- 2014.12) for references. All selected studies were about risk factors of ALRI in children. The screening and quality evalua⁃tion of the literature data was conducted independently by two reviewers according to the inclusion and exclusion criteria. Stata 11.0 software was used for Meta-analysis. Results Meta-analysis of 27 included literature showed that seven risk fac⁃ tors were significantly associated with severe ALRI: low birth weight, lack of exclusive breastfeeding, crowded household, ex⁃ posure to indoor air pollution, malnutrition, living in a house with smokers or smoking in pregnant and HIV-exposed unin⁃ fected condition. Conclusion The above seven risk factors play the important role in the development of ALRI in children. Furthermore, it emphasizes the need for further studies investigating other potential risk factors to decrease the possibility of childhood ALRI.

Key words: respiratory tract infections, acute disease, risk factors, meta-analysis, child